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An 49-year-old pedestrian was struck and seriously injured by a car while crossing Route 66 on Tuesday night, police said. The accident, near the town hall on High Street, was reported 7:40 p.m. The pedestrian, identified as Sylvia Pulino, was taken by ambulance to Middlesex Hospital. A hospital spokeswoman said there is no record of Pulino as a patient. The driver, 18-year-old John Arcidiacono, did not appear to be injured.