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Two were killed and several others injured in the third wrong-way traffic crash in six days, the Arizona Department of Public Safety said.
The latest accident occurred just after 1:30 a.m. Sunday on the Loop 202 near Higley Road in Mesa.
The driver of a pickup truck traveled the wrong way on Loop 202 for about 13 minutes before smashing into an oncoming car, said DPS spokesman Raul Garcia.
"At 1:35 a.m. DPS received the first 911 call. At 1:48 a.m., there was a report of a collision," Garcia said."
The driver and a passenger in the car were killed. Two people in the pickup truck were injured. The driver of the pickup is in serious condition and the passenger is expected to be OK, Garcia said.
No names have been released. Authorities were trying to determine if impairment was a factor in the crash.
It's not known yet how fast the pickup truck was going.
DPS said Loop 202 between Higley Road and Williams Field is closed in both directions.
Police officers from Mesa and Gilbert joined DPS in the investigation.
Sunday morning's deadly crash was the third wrong-way driving accident since May 12.
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