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A pedestrian was seriously injured in a crash that closed most of south Interstate 5 in downtown San Diego for about 40 minutes Thursday afternoon, a California Highway Patrol officer said.

A witness said the person was hit by a passing vehicle while running from the right shoulder of the freeway near Park Boulevard about 1:20 p.m., according to the CHP’s website.

Four of the freeway’s six lanes were closed and traffic was backed up to Old Town Avenue while the crash was investigated.