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Two people, including a wrong-way driver, were killed in a head-on collision in Jefferson County on Tuesday. According to police, a driver exited Highway M and got on southbound Highway 21 going north. The driver, identified as 82-year-old Mary Burke, drove the wrong way for several miles before hitting another vehicle at Shady Valley near Imperial around 12:15 p.m. Burke, of St. Louis, was pronounced dead at the scene. The driver in the other vehicle, identified as James Sybert, 25, was taken to the hospital, where he was later pronounced dead.