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Catherine Greene, 30, Karmen Greene, 9, Santanna Greene, 11, Brayden Greene, 5, Jack Greene, 2, and wrong-way driver Jamaica Natasha Caudill, 38, all die after head-on collision on I-75 in Lexington, Kentucky

Date: 
Saturday, June 5, 2021
Area: 
Lexington, KY

Momin Shoukri, 26, and Rose Portillo, 37, killed after semi-truck crosses into oncoming lanes and collides with other semi head-on, starting fire on I-75 in Cincinnati, Ohio

Date: 
Friday, June 4, 2021
Area: 
Cincinnati, OH

Jessica A. Leitner, 38, and Ann Lynn Garske, 54, dead, George R. Garske, 83, and infant Jordan Leitner critical after wrong-way crash on I-75 in Bay County, Michigan

Date: 
Tuesday, December 27, 2016
Area: 
Flint-Saginaw-Bay City, MI

Jenri R. Velasquez Ruiz, 23, killed, and Abel and Sandra Soriano, and three others injured in head-on wrong-way collision on I-75 in Davie, Florida

Date: 
Saturday, January 16, 2016
Area: 
Miami-Fort Lauderdale, FL

Two people critically injured in crash that closed I-75 between Bristol and Hill Rds in Genesee County, Michigan

Date: 
Friday, March 27, 2015
Area: 
Flint-Saginaw-Bay City, MI

Two people were critically injured in a two-vehicle crash on I-75. The incident began around noon when police recieved reports of a vehicle driving southbound in the northbound lanes. Not long after a crash occured at the Bristol Road overpass. Drivers are advised to seek alternate routes as I-75 between Bristol and Hill Rds is expected to be closed for several more hours.

Sherry Williams, 51, and Christina Rearley, 23, killed and a man and a child injured after wrong-way driver crashes head-on into another vehicle on I-75 in Henry County, Georgia

Date: 
Friday, October 17, 2014
Area: 
Atlanta, GA
A woman driving her car on I-75 south of Hampton Road, going northbound in the southbound lanes, crashed into a car, killing that driver at the scene. Two passengers, a male teenager and a small child, were hurt in the crash, and they are currently hospitalized but in good condition.