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Only the left lane of Interstate 275 was open at Reed Hartman Highway after a multi-vehicle accident.
Dispatchers said several vehicles were involved in an accident just before 6:30 p.m. Sunday.
At least one victim was flown to the hospital, dispatchers said.
Another victim, a child, also suffered serious injuries.
A black Jeep was one vehicle involved in the accident. Officers did not say when all lanes would be open.
The Hamilton County Coroner had been called to the scene but police officers would not confirm that someone was killed in the crash.
The Franklin County Sheriff's Office is investigating a two-vehicle crash involving a semi on the city's west side Wednesday morning.
Deputies responded to Hague Avenue at Fisher Road in Franklin Township at about 8:27 a.m. Wednesday on a report of a crash.
A State Highway Patrol trooper and a driver she was helping after an accident were struck Tuesday when another vehicle lost control on an icy Ohio highway and pushed a cable barrier into them and their vehicles.
The crash happened shortly after midnight along Interstate 70 near Springfield, about 45 miles west of Columbus, as the trooper assisted a 56-year-old Huber Heights woman who had lost control of her vehicle earlier and ended up in the median, the patrol said.
Troopers from the Marion post of the Ohio State Highway Patrol are investigating a fatal crash that occurred in Richland Township early Thursday morning.
Troopers responded to Newmans Cardington Road, east of Claridon Westfield Road, at about 6:22 a.m. on a report of a single-vehicle crash.
According to the report, a 2011 Cadillac CTS two-door driven by 50-year-old Charles E. Orewiler, of Marion, was traveling eastbound on Newmans Cardington Road when the vehicle traveled off the left side of the road, striking a tree. The vehicle rolled and Orewiler was ejected.
All lanes of U.S. Route 62 have reopened following a crash involving multiple vehicles early Thursday morning.
Deputies from the Pickaway County Sheriff's Office responded to U.S. 62 between Mt. Sterling and Harrisburg at about 5:15 a.m.
According to the sheriff's office, the crash involved two semis, a passenger vehicle, and a pickup truck. One of the semis rear-ended the other semi causing it to hit the pickup truck. A passenger vehicle moving the opposite direction struck all of the debris.