Augusta, GATwo people killed in head-on collision on U.S. 221 in McCormick County, South CarolinaAccident Date: Sat, 09/21/2024
Charlotte, NCBruce Schneggenburger, 56, and Stephanie Schneggenburger, 55, died in a head-on collision during heavy rain on U.S. 221 in Ashe County, North CarolinaAccident Date: Sun, 08/06/2023
Greenville-Spartanburg, SC-Asheville, NC-Anderson, SCOne dead, another injured aftera van and a tractor-trailer collided on U.S. 221 in McDowell County, North CarolinaAccident Date: Wed, 04/05/2023
Greenville-Spartanburg, SC-Asheville, NC-Anderson, SCRicky Ronald Jones dies after his pickup truck collides head-on with semi-truck on U.S. 221 in Cherokee County, South CarolinaAccident Date: Thu, 01/26/2023
Greenville-Spartanburg, SC-Asheville, NC-Anderson, SCGregory Allen Thompson-Wilkie, 18, killed after crashing pickup truck into utility pole, causing it to overturn on U.S. 221 in Spartanburg County, South CarolinaAccident Date: Sun, 06/13/2021
Greenville-Spartanburg, SC-Asheville, NC-Anderson, SC Devan Rachad Stevenson, 30, killed and one injured in collision with police vehicle on U.S. 221 near Chesnee, South CarolinaAccident Date: Fri, 12/22/2017
Greenville-Spartanburg, SC-Asheville, NC-Anderson, SC Terry Dixon, 61, Lori Tindel, 44, and Robert Gragg, 48, dead in fiery head-on crash on U.S. 221 north of Marion, North CarolinaAccident Date: Wed, 03/23/2016
Tallahassee, FL-Thomasville, GARonald Anthony Mizell, 68, killed in semi-truck rollover on U.S. 221 near Homerville, GAAccident Date: Wed, 06/24/2015
Roanoke-Lynchburg, VAMichael Keen Haynes, 75, dies in single vehicle crash on U.S. 221 on July 28.Accident Date: Sun, 07/27/2014A Bedford man died after a car crash Monday afternoon.
Charlotte, NCWanda Callaouway, Charles Hutchins, Kasey Whitesides suffer injuries when cars collide on U.S. 221 in Lenoir, North CarolinaAccident Date: Tue, 12/10/2013Three people were taken to the hospital following a two-car collision on U.S. 221 South on Wednesday.